11,299 research outputs found

    Statement of Clifford J. Ehrlich Before the Commission on the Future of Worker-Management Relations

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    Testimony_Ehrlich_022494.pdf: 352 downloads, before Oct. 1, 2020

    Effects of space cabin environments on infection Final report, 19 Jul. 1965 - 18 Sep. 1966

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    Infection resistance and radiation effects on mice determined after varied exposures to space cabin environment and ambient condition

    Longitudinal variations, the opposition effect and monochromatic albedos for Mars

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    Magnitude at zero phase, phase coefficient, and monochromatic albedo computed for Mars as function of wavelengt

    Using molecular mechanics to predict bulk material properties of fibronectin fibers

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    The structural proteins of the extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time scales of cell traction forces. Several proteins such as fibronectin (Fn) and fibrin undergo molecular conformational changes that extend the proteins and are believed to be a major contributor to the extensibility of bulk fibers. The dynamics of these conformational changes have been thoroughly explored since the advent of single molecule force spectroscopy and molecular dynamics simulations but remarkably, these data have not been rigorously applied to the understanding of the time dependent mechanics of bulk ECM fibers. Using measurements of protein density within fibers, we have examined the influence of dynamic molecular conformational changes and the intermolecular arrangement of Fn within fibers on the bulk mechanical properties of Fn fibers. Fibers were simulated as molecular strands with architectures that promote either equal or disparate molecular loading under conditions of constant extension rate. Measurements of protein concentration within micron scale fibers using deep ultraviolet transmission microscopy allowed the simulations to be scaled appropriately for comparison to in vitro measurements of fiber mechanics as well as providing estimates of fiber porosity and water content, suggesting Fn fibers are approximately 75% solute. Comparing the properties predicted by single molecule measurements to in vitro measurements of Fn fibers showed that domain unfolding is sufficient to predict the high extensibility and nonlinear stiffness of Fn fibers with surprising accuracy, with disparately loaded fibers providing the best fit to experiment. This work shows the promise of this microstructural modeling approach for understanding Fn fiber properties, which is generally applicable to other ECM fibers, and could be further expanded to tissue scale by incorporating these simulated fibers into three dimensional network models

    Truncated unity functional renormalization group for multiband systems with spin-orbit coupling

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    Although the functional renormalization group (fRG) is by now a well-established method for investigating correlated electron systems, it is still undergoing significant technical and conceptual improvements. In particular, the motivation to optimally exploit the parallelism of modern computing platforms has recently led to the development of the "truncated-unity" functional renormalization group (TU-fRG). Here, we review this fRG variant, and we provide its extension to multiband systems with spin-orbit coupling. Furthermore, we discuss some aspects of the implementation and outline opportunities and challenges ahead for predicting the ground-state ordering and emergent energy scales for a wide class of quantum materials.Comment: consistent with published version in Frontiers in Physics (2018

    From Age of Consent Laws to the Silver Ring Thing : The Regulation of Adolescent Female Sexuality

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